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World Journal of Engineering Research and Technology

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Engineering Research and Technology

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

ISSN 2454-695X

Impact Factor : 7.029

ICV : 79.45

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Indexing

Abstract

EFFECT OF CEIBA PENTANDRA ON SOME BIOCHEMICAL INDICES OF RATS INDUCED BPH

*Magdalene Obi-Abang and Peter Olom Ube

ABSTRACT

This study assessed the Anti-benign prostatic hyperplasia and biochemical effect of ethanolic extracts of Ceiba pentandra in rat model. Thirty-six (36) BPH induced Male rats were divided into six (6) groups of six rats each. Rats in group one served as normal control and were given rat feed only, Group two (BPH disease Control group), were administered testosterone propionate subcutaneously [3mg/kg b.w], Rats in group three in addition to testosterone propionate (3mg/kg body weight), were administered finasteride (1mg/kg b.w) orally, rats in groups four, five and six, in addition to rats feeds and testosterone propionate were given 2000mg/Kg, 1000mg/Kg and 500mg/Kg body weight extract of Ceiba Pentandra (CP) respectively. The rats were anaesthetized after treatment period. Blood samples were collected and serum harvested for analyses using standard methods. The oral administration of C. pentandra leaves extracts to testosterone induced BPH rats significantly reduced the serum PSA and cretinine concentration in a seemingly dose dependent manner compared to BPHC. The AST and ALP of HD and MD treated groups were considerably reduced compared to BPH control. It is apparent that Ceiba pentandra could attenuate some biochemical parameters in rats induced BPH thereby capable of ameliorating BPH in Wistar rat model.

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