Abstract
PHYSICOCHEMICAL INVESTIGATION OF SOME AMINO ACIDS IN AQUEOUS SOLUTIONS OF AN ANTIVIRAL DRUG AT VARIOUS TEMPERATURES WITH THE MANIFESTATION OF DIVERSE MOLECULAR-INTERACTIONS
Sourav Basu Neogi, Firoj Alam, Biraj Kumar Barman, Subhajit Debnath, Priyanka Roy, Doli Roy, Ankita Shome, Ayesha Hossain, Niladri Sekhar Dutta, Saharukh Hossain and Mahendra Nath Roy*
ABSTRACT
The interaction between the amino acids L-serine and L-threonine and drug molecule amantadine hydrochloride was studied in aqueous medium. A comparative study was performed. It is quite difficult to understand the different degree of interactions of two molecules with structural similarities. To understand the interactions, we studied Density, Viscosity, Conductance as well as surface tension at various concentrations of amino acid molecules and at infinite dilution of thedrug molecule. The deep investigation through the calculation of thermodynamic parameters such as apparent molar volume, viscosity beta coefficient, conductance and surface tension helped to determine the structure making and structure breaking interactions in the ternary solution system. A higher interaction in case of L- threonine and the drug molecule was observed.
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